DNA and Methylation Testing

What Is Methylation and Why Is It Important?

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Methylation is a fundamental biochemical process that occurs billions of times per second in every cell of your body. It involves the transfer of a methyl group (one carbon and three hydrogen atoms) to DNA, proteins, and other molecules — a process essential for maintaining healthy gene expression and overall balance in the body.

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Healthy methylation supports:

• Detoxification: The liver’s ability to neutralise and remove toxins.

• Metabolism: Efficient breakdown of fats, proteins, and carbohydrates.

• DNA synthesis and repair: Protecting your cells from damage and supporting healthy cell turnover.

• Neurotransmitter production: Supporting mood, focus, sleep, and stress resilience.

• Amino acid synthesis: Essential for muscle repair, hormone production, and enzyme function.

• Liver function: Regulating bile flow, hormone metabolism, and toxin elimination.

• Cellular energy production: Supporting mitochondrial health and ATP generation.

• Hormone metabolism: Balancing oestrogen, cortisol, and thyroid hormones.

• Cardiovascular health: Regulating homocysteine and supporting blood vessel integrity.

• Immune system regulation: Helping modulate inflammation and immune response.

 

When methylation becomes impaired due to genetic variations, nutrient deficiencies, or environmental stressors — the body can experience fatigue, anxiety, poor detoxification, hormonal imbalances, fertility issues, and a higher susceptibility to chronic disease. Understanding your genetic blueprint allows for a highly individualised approach to restoring optimal methylation function.

 

What Does the Methylation Genetic Test Assess?

 

This comprehensive test analyses 111 genes and 129 single nucleotide polymorphisms (SNPs), providing deep insight into your body’s biochemical pathways. It helps identify where genetic variations may be influencing your metabolism, mood, energy, or detoxification ability.

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Key functional areas include:

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• Nervous System & Mental Health – Genes such as COMT and MAO influence how you metabolise dopamine, serotonin, and adrenaline, which can impact stress tolerance, anxiety, and emotional regulation.

• Detoxification Pathways – Genes including GST, CBS, and SUOX affect sulphur metabolism and liver detox capacity, revealing how well your body processes environmental toxins, alcohol, and medications.

• Hormonal Balance – Genes that regulate oestrogen metabolism and endocrine function, influencing PMS, menopause, and reproductive health.

• Energy Production – Mitochondrial and Krebs cycle genes related to ATP synthesis and fatigue patterns.

• Digestive Health – Variants such as FUT2 and DAO can influence gut microbiome diversity, nutrient absorption, and histamine intolerance.

• Inflammation & Longevity – Genes that regulate inflammatory cytokines and oxidative stress, influencing cellular ageing.

• Cardiovascular Health – Genes like MTHFR, MTR, and MTRR play a key role in homocysteine recycling and vascular integrity.

 

This testing is performed by a NATA-accredited Australian laboratory, ensuring scientific precision and reliability.

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Who Can Benefit from This Testing?

 

Individuals who may find this testing particularly beneficial include those experiencing:

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• Cardiovascular concerns: Such as high homocysteine levels or a family history of heart disease.

• Mood and Mental Health issues: Including depression, anxiety, bipolar disorder, and schizophrenia.

• Detoxification issues: Difficulty in processing toxins, sensitivity to medications, or exposure to environmental pollutants.

• Chronic fatigue and low energy: Unexplained tiredness that may be linked to mitochondrial dysfunction.

• Cognitive decline: Memory issues or concerns about neurodegenerative diseases.

• Chronic fatigue, burnout, or low vitality.

• Hormonal imbalances such as PMS, endometriosis, fertility challenges, or menopausal symptoms.

• Gut and histamine issues including bloating, food sensitivities, or irregular digestion.

• Poor stress tolerance, sleep issues, or cognitive fog.

 

By identifying specific genetic variants, we can develop targeted nutritional and lifestyle interventions to support optimal methylation and overall health.